- Lesions associated with significant mass effect should not undergo stereotactic biopsy due to the likelihood of swelling and postoperative neurologic worsening after biopsy.
- Lesions that are possibly vascular pathologies, such as arteriovenous malformations, should not undergo stereotactic biopsy due to the risk of haemorrhage.
- Patients with hematologic disorders may need temporary correction of their disorders prior to undergoing the procedure.
- Very superficial lesion
- Very large lesion